The REVAMP trial to evaluate HIV resistance testing in sub-Saharan Africa: a case study in clinical trial design in resource limited settings to optimize effectiveness and cost effectiveness estimates.
Identifieur interne : 000162 ( Main/Exploration ); précédent : 000161; suivant : 000163The REVAMP trial to evaluate HIV resistance testing in sub-Saharan Africa: a case study in clinical trial design in resource limited settings to optimize effectiveness and cost effectiveness estimates.
Auteurs : Mark J. Siedner [États-Unis] ; Mwebesa B. Bwana [Ouganda] ; Mahomed-Yunus S. Moosa [Afrique du Sud] ; Michelle Paul [États-Unis] ; Selvan Pillay [Afrique du Sud] ; Suzanne Mccluskey [États-Unis] ; Isaac Aturinda [Ouganda] ; Kevin Ard [États-Unis] ; Winnie Muyindike [Ouganda] ; Pravikrishnen Moodley [Afrique du Sud] ; Jaysingh Brijkumar [Afrique du Sud] ; Tamlyn Rautenberg [Afrique du Sud] ; Gavin George [Afrique du Sud] ; Brent Johnson [États-Unis] ; Rajesh T. Gandhi [États-Unis] ; Henry Sunpath [Afrique du Sud] ; Vincent C. Marconi [États-Unis]Source :
- HIV clinical trials [ 1945-5771 ] ; 2017.
Abstract
In sub-Saharan Africa, rates of sustained HIV virologic suppression remain below international goals. HIV resistance testing, while common in resource-rich settings, has not gained traction due to concerns about cost and sustainability.
DOI: 10.1080/15284336.2017.1349028
PubMed: 28720039
Affiliations:
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Siedner</name><affiliation wicri:level="2"><nlm:affiliation>a Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Department of Medicine , Massachusetts General Hospital , Boston , MA </wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bwana, Mwebesa B" sort="Bwana, Mwebesa B" uniqKey="Bwana M" first="Mwebesa B" last="Bwana">Mwebesa B. Bwana</name><affiliation wicri:level="1"><nlm:affiliation>b Faculty of Medicine , Mbarara University of Science and Technology , Mbarara , Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>b Faculty of Medicine , Mbarara University of Science and Technology , Mbarara </wicri:regionArea><wicri:noRegion>Mbarara </wicri:noRegion></affiliation></author><author><name sortKey="Moosa, Mahomed Yunus S" sort="Moosa, Mahomed Yunus S" uniqKey="Moosa M" first="Mahomed-Yunus S" last="Moosa">Mahomed-Yunus S. Moosa</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="Paul, Michelle" sort="Paul, Michelle" uniqKey="Paul M" first="Michelle" last="Paul">Michelle Paul</name><affiliation wicri:level="2"><nlm:affiliation>a Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Department of Medicine , Massachusetts General Hospital , Boston , MA </wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pillay, Selvan" sort="Pillay, Selvan" uniqKey="Pillay S" first="Selvan" last="Pillay">Selvan Pillay</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="Mccluskey, Suzanne" sort="Mccluskey, Suzanne" uniqKey="Mccluskey S" first="Suzanne" last="Mccluskey">Suzanne Mccluskey</name><affiliation wicri:level="2"><nlm:affiliation>a Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Department of Medicine , Massachusetts General Hospital , Boston , MA </wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Aturinda, Isaac" sort="Aturinda, Isaac" uniqKey="Aturinda I" first="Isaac" last="Aturinda">Isaac Aturinda</name><affiliation wicri:level="1"><nlm:affiliation>b Faculty of Medicine , Mbarara University of Science and Technology , Mbarara , Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>b Faculty of Medicine , Mbarara University of Science and Technology , Mbarara </wicri:regionArea><wicri:noRegion>Mbarara </wicri:noRegion></affiliation></author><author><name sortKey="Ard, Kevin" sort="Ard, Kevin" uniqKey="Ard K" first="Kevin" last="Ard">Kevin Ard</name><affiliation wicri:level="2"><nlm:affiliation>a Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Department of Medicine , Massachusetts General Hospital , Boston , MA </wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Muyindike, Winnie" sort="Muyindike, Winnie" uniqKey="Muyindike W" first="Winnie" last="Muyindike">Winnie Muyindike</name><affiliation wicri:level="1"><nlm:affiliation>b Faculty of Medicine , Mbarara University of Science and Technology , Mbarara , Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>b Faculty of Medicine , Mbarara University of Science and Technology , Mbarara </wicri:regionArea><wicri:noRegion>Mbarara </wicri:noRegion></affiliation></author><author><name sortKey="Moodley, Pravikrishnen" sort="Moodley, Pravikrishnen" uniqKey="Moodley P" first="Pravikrishnen" last="Moodley">Pravikrishnen Moodley</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="Brijkumar, Jaysingh" sort="Brijkumar, Jaysingh" uniqKey="Brijkumar J" first="Jaysingh" last="Brijkumar">Jaysingh Brijkumar</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="Rautenberg, Tamlyn" sort="Rautenberg, Tamlyn" uniqKey="Rautenberg T" first="Tamlyn" last="Rautenberg">Tamlyn Rautenberg</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="George, Gavin" sort="George, Gavin" uniqKey="George G" first="Gavin" last="George">Gavin George</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Brent" sort="Johnson, Brent" uniqKey="Johnson B" first="Brent" last="Johnson">Brent Johnson</name><affiliation wicri:level="2"><nlm:affiliation>e Department of Biostatistics and Computational Biology , University of Rochester , Rochester , NY , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>e Department of Biostatistics and Computational Biology , University of Rochester , Rochester , NY </wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gandhi, Rajesh T" sort="Gandhi, Rajesh T" uniqKey="Gandhi R" first="Rajesh T" last="Gandhi">Rajesh T. Gandhi</name><affiliation wicri:level="2"><nlm:affiliation>a Department of Medicine , Massachusetts General Hospital , Boston , MA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Department of Medicine , Massachusetts General Hospital , Boston , MA </wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sunpath, Henry" sort="Sunpath, Henry" uniqKey="Sunpath H" first="Henry" last="Sunpath">Henry Sunpath</name><affiliation wicri:level="1"><nlm:affiliation>c Division of Medicine , University of KwaZulu-Natal , Durban , South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>c Division of Medicine , University of KwaZulu-Natal , Durban </wicri:regionArea><wicri:noRegion>Durban </wicri:noRegion></affiliation></author><author><name sortKey="Marconi, Vincent C" sort="Marconi, Vincent C" uniqKey="Marconi V" first="Vincent C" last="Marconi">Vincent C. Marconi</name><affiliation wicri:level="2"><nlm:affiliation>d Department of Medicine , Emory University , Atlanta , GA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>d Department of Medicine , Emory University , Atlanta , GA </wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">HIV clinical trials</title><idno type="eISSN">1945-5771</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In sub-Saharan Africa, rates of sustained HIV virologic suppression remain below international goals. HIV resistance testing, while common in resource-rich settings, has not gained traction due to concerns about cost and sustainability.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Ouganda</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Massachusetts</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Siedner, Mark J" sort="Siedner, Mark J" uniqKey="Siedner M" first="Mark J" last="Siedner">Mark J. Siedner</name></region><name sortKey="Ard, Kevin" sort="Ard, Kevin" uniqKey="Ard K" first="Kevin" last="Ard">Kevin Ard</name><name sortKey="Gandhi, Rajesh T" sort="Gandhi, Rajesh T" uniqKey="Gandhi R" first="Rajesh T" last="Gandhi">Rajesh T. Gandhi</name><name sortKey="Johnson, Brent" sort="Johnson, Brent" uniqKey="Johnson B" first="Brent" last="Johnson">Brent Johnson</name><name sortKey="Marconi, Vincent C" sort="Marconi, Vincent C" uniqKey="Marconi V" first="Vincent C" last="Marconi">Vincent C. Marconi</name><name sortKey="Mccluskey, Suzanne" sort="Mccluskey, Suzanne" uniqKey="Mccluskey S" first="Suzanne" last="Mccluskey">Suzanne Mccluskey</name><name sortKey="Paul, Michelle" sort="Paul, Michelle" uniqKey="Paul M" first="Michelle" last="Paul">Michelle Paul</name></country><country name="Ouganda"><noRegion><name sortKey="Bwana, Mwebesa B" sort="Bwana, Mwebesa B" uniqKey="Bwana M" first="Mwebesa B" last="Bwana">Mwebesa B. Bwana</name></noRegion><name sortKey="Aturinda, Isaac" sort="Aturinda, Isaac" uniqKey="Aturinda I" first="Isaac" last="Aturinda">Isaac Aturinda</name><name sortKey="Muyindike, Winnie" sort="Muyindike, Winnie" uniqKey="Muyindike W" first="Winnie" last="Muyindike">Winnie Muyindike</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Moosa, Mahomed Yunus S" sort="Moosa, Mahomed Yunus S" uniqKey="Moosa M" first="Mahomed-Yunus S" last="Moosa">Mahomed-Yunus S. Moosa</name></noRegion><name sortKey="Brijkumar, Jaysingh" sort="Brijkumar, Jaysingh" uniqKey="Brijkumar J" first="Jaysingh" last="Brijkumar">Jaysingh Brijkumar</name><name sortKey="George, Gavin" sort="George, Gavin" uniqKey="George G" first="Gavin" last="George">Gavin George</name><name sortKey="Moodley, Pravikrishnen" sort="Moodley, Pravikrishnen" uniqKey="Moodley P" first="Pravikrishnen" last="Moodley">Pravikrishnen Moodley</name><name sortKey="Pillay, Selvan" sort="Pillay, Selvan" uniqKey="Pillay S" first="Selvan" last="Pillay">Selvan Pillay</name><name sortKey="Rautenberg, Tamlyn" sort="Rautenberg, Tamlyn" uniqKey="Rautenberg T" first="Tamlyn" last="Rautenberg">Tamlyn Rautenberg</name><name sortKey="Sunpath, Henry" sort="Sunpath, Henry" uniqKey="Sunpath H" first="Henry" last="Sunpath">Henry Sunpath</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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